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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE4A All Species: 45.76
Human Site: S1010 Identified Species: 71.9
UniProt: Q14139 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14139 NP_004779.2 1066 122561 S1010 D P V V L P S S R V T V D R S
Chimpanzee Pan troglodytes XP_001161169 1066 122495 S1010 D P V V L P S S R V T V D R S
Rhesus Macaque Macaca mulatta XP_001097812 1067 122494 Q1010 D P V V L A T Q E A E A D R L
Dog Lupus familis XP_850081 1066 122542 S1010 D P V V L P S S R V T V D R S
Cat Felis silvestris
Mouse Mus musculus Q9ES00 1173 133285 G1121 D P V R L P S G T V M D R S I
Rat Rattus norvegicus Q6P7A2 1066 122361 S1010 D P V V L P S S R V T V D G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026081 1074 123247 S1014 D P V I L P S S R V T V D R S
Frog Xenopus laevis NP_001084506 1072 122544 S1012 D P V I L P S S R V T V D R S
Zebra Danio Brachydanio rerio XP_001922961 1078 122949 S1019 D P V L L P S S N V T V D R S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609060 993 113046 S937 D P V V L P S S K V T V D R S
Honey Bee Apis mellifera XP_393070 965 109934 S908 D P V I L P S S K I T I D R Q
Nematode Worm Caenorhab. elegans Q09349 980 113212 S927 V D P V K L P S G H V M D R A
Sea Urchin Strong. purpuratus XP_786748 942 107668 L894 A S E Q V V V L L L N E C S Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LF41 1038 117510 S963 D P V I L P S S R I T V D R P
Baker's Yeast Sacchar. cerevisiae P54860 961 109887 S903 D P V I L P A S K M N I D R S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.1 98.6 N.A. 24.6 97 N.A. N.A. 87.7 79.7 76.7 N.A. 33.1 36.5 22.9 32.7
Protein Similarity: 100 100 98.5 99.4 N.A. 45.2 99 N.A. N.A. 94.3 90.8 87.4 N.A. 51.3 54.5 42.5 52.2
P-Site Identity: 100 100 46.6 100 N.A. 46.6 93.3 N.A. N.A. 93.3 93.3 86.6 N.A. 93.3 66.6 26.6 0
P-Site Similarity: 100 100 53.3 100 N.A. 46.6 93.3 N.A. N.A. 100 100 93.3 N.A. 100 93.3 40 13.3
Percent
Protein Identity: N.A. N.A. N.A. 25.3 22.9 N.A.
Protein Similarity: N.A. N.A. N.A. 43.9 41.6 N.A.
P-Site Identity: N.A. N.A. N.A. 80 60 N.A.
P-Site Similarity: N.A. N.A. N.A. 93.3 93.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 7 7 0 0 7 0 7 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 87 7 0 0 0 0 0 0 0 0 0 7 87 0 0 % D
% Glu: 0 0 7 0 0 0 0 0 7 0 7 7 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 7 7 0 0 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % H
% Ile: 0 0 0 34 0 0 0 0 0 14 0 14 0 0 7 % I
% Lys: 0 0 0 0 7 0 0 0 20 0 0 0 0 0 0 % K
% Leu: 0 0 0 7 87 7 0 7 7 7 0 0 0 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 7 7 7 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 7 0 14 0 0 0 0 % N
% Pro: 0 87 7 0 0 80 7 0 0 0 0 0 0 0 7 % P
% Gln: 0 0 0 7 0 0 0 7 0 0 0 0 0 0 7 % Q
% Arg: 0 0 0 7 0 0 0 0 47 0 0 0 7 80 0 % R
% Ser: 0 7 0 0 0 0 74 80 0 0 0 0 0 14 60 % S
% Thr: 0 0 0 0 0 0 7 0 7 0 67 0 0 0 0 % T
% Val: 7 0 87 47 7 7 7 0 0 60 7 60 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _